Methods:There were included 193 subjects with MCI, aged over 65. They were evaluated after 6 months, 1 year and 2 years of treatment using Mini Mental State Examination (MMSE) and clock test.
Group A -43 patients treated with piracetamum(daily dose:1600 mg).
Group B that comprises 44 patients diagnosed with MCI treated with rhodiola rosea, 2 capsules/day.
Group C -41 patients which were treated with antioxidant agents(vitaminE 800ui/day).
Group D -36 subjects treated with piracetamum associated with rhodiola rosea and vitamin E.
Group E -29 patients without treatment.
Results:Mean of MMSE score at inclusion was 24,49 (SD = 2,1). After 6 months of treatment MMSE score improve in groups treated with 1,35 points in group A, 1,41 for group B, 1,12 points for group C, 1,18 points in group D and in group E we observed an impairment with 0,52 points. in groups A, B, C and D after 1 year of treatment the improvement is with 2,07; 2,03, 2,68 and 3,03 points comparing with the impairment in group E of 1,69 points. Evaluation after 2 years of treatment show a better improvement for group D (3,3 points), followed by group C (2,63 points), group B (2,43 points) and group A (2,23 points) and a greater impairment in group E (2,49 points).